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Publications
  1. Cremasco V, Astarita JL, Grauel AL, Keerthivasan S, MacIsaac K, Woodruff MC, Wu M, Spel L, Santoro S, Amoozgar Z, Laszewski T, Migoni SC, Knoblich K, Fletcher AL, LaFleur M, Wucherpfennig KW, Pure E, Dranoff G, Carroll MC, Turley SJ. FAP Delineates Heterogeneous and Functionally Divergent Stromal Cells in Immune-Excluded Breast Tumors. Cancer Immunol Res. 2018;6: 1472–1485. doi:10.1158/2326-6066.CIR-18-0098 PMID: 30266714
  2. Abuwarwar MH, Knoblich K, Fletcher AL. A pathogenic hierarchy for synovial fibroblasts in rheumatoid arthritis. Ann Transl Med. 2018;0. doi:10.21037/22214
  3. Knoblich K, Cruz Migoni S, Siew SM, Jinks E, Kaul B, Jeffery HC, Baker AT, Suliman M, Vrzalikova K, Mehenna H, Murray PG, Barone F, Oo YH, Newsome PN, Hirschfield G, Kelly D, Lee SP, Parekkadan B, Turley SJ, Fletcher AL. The human lymph node microenvironment unilaterally regulates T-cell activation and differentiation. PLoS Biol. 2018 Sep 4;16(9):e2005046. doi: 10.1371/journal.pbio.2005046 eCollection 2018 Sep PMID: 30180168
  4. D’Rozario J, Roberts D, Suliman M, Knoblich K, Fletcher A. Leukocyte-Stromal Interactions Within Lymph Nodes. Adv Exp Med Biol. 2018;1060:1-22. doi: 10.1007/978-3-319-78127-3_1. PMID: 30155619
  5. Zhang Y, Tech L, George LA, Acs A, Durrett RE, Hess H, Walker LSK, Tarlinton DM, Fletcher AL, Hauser AE, Toellner KM. Plasma cell output from germinal centers is regulated by signals from Tfh and stromal cells. J Exp Med. 2018 Apr 2;215(4):1227-1243. doi: 10.1084/jem.20160832. Epub 2018 Mar 16. PMID:29549115
  6. Sharma C, Wang HX, Li Q, Knoblich K, Reisenbichler ES, Richardson AL, Hemler ME. Protein acyltransferase DHHC3 regulates breast tumor growth, oxidative stress and senescence. Cancer Res. 2017 Oct 20. pii: canres.1536.2017. doi: 10.1158/0008-5472.CAN-17-1536. Epub 2017 Oct 20 PMID:29055014
  7. Fletcher AL, Heng TS. Lymph node stroma join the cancer support network. Cell Death Differ. 2016 Dec;23(12):1899-1901. doi: 10.1038/cdd.2016.103. Epub 2016 Sep 30. PMID:27689877
  8. van ‘t Hag L, Knoblich K, Seabrook SA, Kirby NM, Mudie ST, Lau D, Li X, Gras SL, Mulet X, Call ME, Call MJ, Drummond CJ, Conn CE. Exploring the in meso crystallization mechanism by characterizing the lipid mesophase microenvironment during the growth of single transmembrane α-helical peptide crystals. Philos Trans A Math Phys Eng Sci. 2016 Jul 28;374(2072). pii: 20150125. doi: 10.1098/rsta.2015.0125. PubMed PMID: 27298442; PubMed Central PMCID: PMC4920275.
  9. Fletcher AL, Acton SE, Knoblich K. Lymph node fibroblastic reticular cells in health and disease. Nat Rev Immunol. 2015 Jun;15(6):350-61. Review. PubMed PMID: 25998961.
  10. Knoblich K, Park S, Lutfi M, van ‘t Hag L, Conn CE, Seabrook SA, Newman J, Czabotar PE, Im W, Call ME, Call MJ. Transmembrane Complexes of DAP12 Crystallized in Lipid Membranes Provide Insights into Control of Oligomerization in Immunoreceptor Assembly. Cell Rep. 2015 May 26;11(8):1184-92. doi:10.1016/j.celrep.2015.04.045. Epub 2015 May 14. PubMed PMID: 25981043; PubMed Central PMCID: PMC4449314.
  11. Wang HX, Sharma C, Knoblich K, Granter SR, Hemler ME. EWI-2 negatively regulates TGF-β signaling leading to altered melanoma growth and metastasis. Cell Res. 2015 Mar;25(3):370-85. doi: 10.1038/cr.2015.17. Epub 2015 Feb 6. PubMed PMID: 25656846; PubMed Central PMCID: PMC4349253.
  12. Fletcher AL, Elman JS, Astarita J, Murray R, Saeidi N, D’Rozario J, Knoblich K, Brown FD, Schildberg FA, Nieves JM, Heng TS, Boyd RL, Turley SJ, Parekkadan B. Lymph node fibroblastic reticular cell transplants show robust therapeutic efficacy in high-mortality murine sepsis. Sci Transl Med. 2014 Aug 13;6(249):249ra109. doi: 10.1126/scitranslmed.3009377. PubMed PMID: 25122637; PubMed Central PMCID: PMC4415170.
  13. Knoblich K, Wang HX, Sharma C, Fletcher AL, Turley SJ, Hemler ME. Tetraspanin  TSPAN12 regulates tumor growth and metastasis and inhibits β-catenin degradation. Cell Mol Life Sci. 2014 Apr;71(7):1305-14. doi: 10.1007/s00018-013-1444-8. Epub 2013 Aug 18. PubMed PMID: 23955570.
  14. Malhotra D, Fletcher AL, Turley SJ. Stromal and hematopoietic cells in secondary lymphoid organs: partners in immunity. Immunol Rev. 2013 Jan;251(1):160-76. doi: 10.1111/imr.12023. Review. PubMed PMID: 23278748; PubMed Central PMCID: PMC3539229.
  15. Acton SE, Astarita JL, Malhotra D, Lukacs-Kornek V, Franz B, Hess PR, Jakus Z, Kuligowski M, Fletcher AL, Elpek KG, Bellemare-Pelletier A, Sceats L, Reynoso ED, Gonzalez SF, Graham DB, Chang J, Peters A, Woodruff M, Kim YA, Swat W, Morita T,  Kuchroo V, Carroll MC, Kahn ML, Wucherpfennig KW, Turley SJ. Podoplanin-rich stromal networks induce dendritic cell motility via activation of the C-type lectin receptor CLEC-2. Immunity. 2012 Aug 24;37(2):276-89. doi: 10.1016/j.immuni.2012.05.022. Epub 2012 Aug 9. PubMed PMID: 22884313; PubMed Central PMCID: PMC3556784.
  16. Li Q, Yang XH, Xu F, Sharma C, Wang HX, Knoblich K, Rabinovitz I, Granter SR,  Hemler ME. Tetraspanin CD151 plays a key role in skin squamous cell carcinoma. Oncogene. 2013 Apr 4;32(14):1772-83. doi: 10.1038/onc.2012.205. Epub 2012 Jul 23. PubMed PMID: 22824799; PubMed Central PMCID: PMC3482293.
  17. Malhotra D, Fletcher AL, Astarita J, Lukacs-Kornek V, Tayalia P, Gonzalez SF, Elpek KG, Chang SK, Knoblich K, Hemler ME, Brenner MB, Carroll MC, Mooney DJ, Turley SJ; Immunological Genome Project Consortium. Transcriptional profiling of  stroma from inflamed and resting lymph nodes defines immunological hallmarks. Nat Immunol. 2012 Apr 1;13(5):499-510. doi: 10.1038/ni.2262. PubMed PMID: 22466668; PubMed Central PMCID: PMC3366863.
  18. Parekkadan B, Fletcher AL, Li M, Tjota MY, Bellemare-Pelletier A, Milwid JM,  Lee JW, Yarmush ML, Turley SJ. Aire controls mesenchymal stem cell-mediated suppression in chronic colitis. Mol Ther. 2012 Jan;20(1):178-86. doi: 10.1038/mt.2011.192. Epub 2011 Sep 27. PubMed PMID: 21952165; PubMed Central PMCID: PMC3255580.
  19. Lukacs-Kornek V, Malhotra D, Fletcher AL, Acton SE, Elpek KG, Tayalia P, Collier AR, Turley SJ. Regulated release of nitric oxide by nonhematopoietic stroma controls expansion of the activated T cell pool in lymph nodes. Nat Immunol. 2011 Sep 18;12(11):1096-104. doi: 10.1038/ni.2112. PubMed PMID: 21926986; PubMed Central PMCID: PMC3457791.
  20. Alikhan MA, Jones CV, Williams TM, Beckhouse AG, Fletcher AL, Kett MM, Sakkal S, Samuel CS, Ramsay RG, Deane JA, Wells CA, Little MH, Hume DA, Ricardo SD. Colony-stimulating factor-1 promotes kidney growth and repair via alteration of macrophage responses. Am J Pathol. 2011 Sep;179(3):1243-56. doi: 10.1016/j.ajpath.2011.05.037. Epub 2011 Jul 14. PubMed PMID: 21762674; PubMed Central PMCID: PMC3157188.
  21. Fletcher AL, Calder A, Hince MN, Boyd RL, Chidgey AP. The contribution of thymic stromal abnormalities to autoimmune disease. Crit Rev Immunol. 2011;31(3):171-87. Review. PubMed PMID: 21740349.
  22. Lv H, Havari E, Pinto S, Gottumukkala RV, Cornivelli L, Raddassi K, Matsui T, Rosenzweig A, Bronson RT, Smith R, Fletcher AL, Turley SJ, Wucherpfennig K, Kyewski B, Lipes MA. Impaired thymic tolerance to α-myosin directs autoimmunity to the heart in mice and humans. J Clin Invest. 2011 Apr;121(4):1561-73. doi: 10.1172/JCI44583. Epub 2011 Mar 23. PubMed PMID: 21436590; PubMed Central PMCID: PMC3069776.
  23. Wang HX, Li Q, Sharma C, Knoblich K, Hemler ME. Tetraspanin protein contributions to cancer. Biochem Soc Trans. 2011 Apr;39(2):547-52. doi: 10.1042/BST0390547. Review. PubMed PMID: 21428937.
  24. Fletcher AL, Malhotra D, Acton SE, Lukacs-Kornek V, Bellemare-Pelletier A, Curry M, Armant M, Turley SJ. Reproducible isolation of lymph node stromal cells reveals site-dependent differences in fibroblastic reticular cells. Front Immunol. 2011 Sep 12;2:35. doi: 10.3389/fimmu.2011.00035. eCollection 2011. PubMed PMID: 22566825; PubMed Central PMCID: PMC3342056.
  25. Fletcher AL, Malhotra D, Turley SJ. Lymph node stroma broaden the peripheral tolerance paradigm. Trends Immunol. 2011 Jan;32(1):12-8. doi: 10.1016/j.it.2010.11.002. Epub 2010 Dec 10. Review. PubMed PMID: 21147035; PubMed Central PMCID: PMC3163075.
  26. Turley SJ, Fletcher AL, Elpek KG. The stromal and haematopoietic antigen-presenting cells that reside in secondary lymphoid organs. Nat Rev Immunol. 2010 Dec;10(12):813-25. doi: 10.1038/nri2886. Epub 2010 Nov 19. Review. PubMed PMID: 21088682.
  27. Fletcher AL, Lukacs-Kornek V, Reynoso ED, Pinner SE, Bellemare-Pelletier A, Curry MS, Collier AR, Boyd RL, Turley SJ. Lymph node fibroblastic reticular cells directly present peripheral tissue antigen under steady-state and inflammatory conditions. J Exp Med. 2010 Apr 12;207(4):689-97. doi: 10.1084/jem.20092642. Epub 2010 Mar 22. PubMed PMID: 20308362; PubMed Central PMCID: PMC2856033.
  28. Gardner JM, Fletcher AL, Anderson MS, Turley SJ. AIRE in the thymus and beyond. Curr Opin Immunol. 2009 Dec;21(6):582-9. doi: 10.1016/j.coi.2009.08.007. Epub 2009 Oct 14. Review. PubMed PMID: 19833494; PubMed Central PMCID: PMC2787634.
  29. Knoblich K, Whittaker S, Ludwig C, Michiels P, Jiang T, Schaffhausen B,
    Günther U. Backbone assignment of the N-terminal polyomavirus large T antigen. Biomol NMR Assign. 2009 Jun;3(1):119-23. doi: 10.1007/s12104-009-9155-7. Epub 2009 Apr 9. PubMed PMID: 19636961.
  30. Fletcher AL, Lowen TE, Sakkal S, Reiseger JJ, Hammett MV, Seach N, Scott HS, Boyd RL, Chidgey AP. Ablation and regeneration of tolerance-inducing medullary thymic epithelial cells after cyclosporine, cyclophosphamide, and dexamethasone treatment. J Immunol. 2009 Jul 15;183(2):823-31. doi: 10.4049/jimmunol.0900225. Epub 2009 Jun 29. PubMed PMID: 19564346.
  31. Fletcher AL, Seach N, Reiseger JJ, Lowen TE, Hammett MV, Scott HS, Boyd RL. Reduced thymic Aire expression and abnormal NF-kappa B2 signaling in a model of systemic autoimmunity. J Immunol. 2009 Mar 1;182(5):2690-9. doi: 10.4049/jimmunol.0801752. PubMed PMID: 19234163.
  32. Seach N, Ueno T, Fletcher AL, Lowen T, Mattesich M, Engwerda CR, Scott HS, Ware CF, Chidgey AP, Gray DH, Boyd RL. The lymphotoxin pathway regulates Aire-independent expression of ectopic genes and chemokines in thymic stromal cells. J Immunol. 2008 Apr 15;180(8):5384-92. PubMed PMID: 18390720; PubMed Central PMCID: PMC2760078.
  33. Gray DH, Fletcher AL, Hammett M, Seach N, Ueno T, Young LF, Barbuto J, Boyd RL, Chidgey AP. Unbiased analysis, enrichment and purification of thymic stromal cells. J Immunol Methods. 2008 Jan 1;329(1-2):56-66. Epub 2007 Oct 23. PubMed PMID: 17988680.

Discussion

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